16 бит на слух не может быть лучше 24.

Reason uses 32-bit floating point arithmetic for all internal audio operations, with 64-bit summing in the mix bus in the Main Mixer Master Section.
This ensures the highest possible audio quality throughout the entire signal chain.
• Reason supports 16, 20, and 24 bit resolution for input and output audio.
• Reason supports all standard sample rates between 44.1 kHz and 192 kHz.
Reason also supports lower sampling frequencies, but using a sample rate of less than 44.1 kHz is not recommended since it might affect the audio quality negatively.

The Reason sequencer supports import of mono and stereo audio files of various formats, sample rates and resolutions. Reason also supports import of REX (ReCycle rcy, rex and rx2) files. You can import several audio files at the same time, with each audio file ending up on a separate Audio Track in the sequencer - or on separate Comp Rows in a selected Audio Clip. You can import files of different formats on the same Audio Track - or even in the same Audio Clip. One audio file could be an 8-bit mono file sampled at 22.05 kHz, the next a 24-bit stereo file sampled at 192 kHz, etc. Reason automatically converts sample rates and resolution with preserved audio quality. If the imported audio file includes tempo data that Reason supports, Reason automatically matches (stretches) the audio file to fit the current Song Tempo, without affecting the pitch. • if the imported audio files’ sample rates differ from the current audio hardware sample rate, Reason will automatically sample rate convert.

Reason handles all internal audio processing in 32-bit floating point resolution. However, the resolution of the input and output audio is determined by the hardware audio interface. That is, if you have a 24-bit audio card, Reason will record and output audio in 24-bit resolution, and if you have a 20-bit audio card, audio will be recorded and played back in 20-bit resolution.

Reason supports files of a large number of sample rates and resolutions. You can use files of different formats
in the same device - one drum sound can be an 8-bit sample, the next a 16-bit or 24-bit sample, etc. Whenever you sample in Reason, the resulting audio files are stored in WAV format. The sample rate is determined by the settings on the Audio tab in Preferences (see “Audio settings”). The resolution (bit depth) is defined in the setup application for your specific audio hardware (consult the manual for your audio hardware for information). Actually, Reason is totally agnostic about what sample rate and resolution you use. If you like, you can change audio settings at any time without affecting the pitch, playback speed etc. of your samples. What you have once sampled will always sound the same, regardless of the current audio settings!